结直肠癌病人手术前后血、尿和唾液中表皮生长因子的含量变化

The changes of epidermal growth factor concentrations in the blood,urine and saliva of the patients with colorectal cancer before and after operation

用放射免疫方法定量检测结直肠癌病人手术前后血、尿和唾液中表皮生长因子(EGF)含量的变化。结果发现,术后病人血清和唾液中EGF含量较术前显著降低,趋近正常对照。但尿EGF术前术后比较无显著性差异。因此,可认为EGF在结直肠癌的发生发展中起重要作用。

Epidermal growth factor (EGF)in the ser- a, urine and saliva of the patients with colorec- tal cancer before and after operation, were as- sessed by the RIA method. The results showed that EGF in sera and saliva of the pa- tients after operation decreased significantly as compared with that of patients before opera- tion and was near to that of controls. EGF in urine of the patients. however, revealed no dif- ference before and after operation. The results suggest that EGF plays an important role in the development of colorectal cancer.