亚胺培南／西司他丁等对MRSA和MSSA的体外抗菌活性研究

Study on the in vitro antibacterial activity of impenem/cilastatin against MRSA and MSSA

用琼脂稀释法对亚胺培南／西司他丁等７种抗生素进行了对临床分离的１０４株耐甲氧西林金葡球菌（ＭＲＳＡ）和１２０株甲氧西林敏感的金葡球菌（ＭＳＳＡ）的体外抗菌活性比较，结果表明亚胺培南／西司他丁和去甲万古霉素的抗菌活性最强，对ＭＲＳＡ的ＭＩＣ＿（９０）分别为４和２μｇ／ｍｌ，对ＭＳＳＡ的ＭＩＣ＿（９０）为１和２μｇ／ｍｌ。其它５种抗生素对ＭＲＳＡ的抑菌作用均较差。但其中的头孢唑林和头孢拉定对ＭＳＳＡ的抑菌作用较好，１２０株ＭＳＳＡ对两者的敏感率分别为９０％和７４．１７％。

The in vitro susceptibilities of 104 strains of methicillin-resistant Staphylococcus aureus(MRSA) and 120 methicillin-sensitive Staphylococcus aureus(MSSA)to seven antibiotics(including imipenem/cilastatin, norvancomycin, cefazolin,cefradine,penicillin G, ampicillin and lincomycin ) were determined by the agar dilution method.Results demonstrated that imipenem/cilastatin and norvancomycin were among the strengest,the MIC_(90) of imipenem/ cilastatin and norvancomycin that inhibited MRSA tested were 4 and 2 μg/ml, of MSSA were 1 and 2μg/ml, respectively. But the in vitro antibacterial activities against MRSA of all other five kinds of antibiotics were disappointed.However, the antibacterial activities of cefazolin and cefradine against MSSA were more active than the others, and 90%and 74. 14% of MSSA were susceptible, respectively.