摘要
较大剂量的助阳益气中药党参、黄芪、仙灵脾、附子、肉桂、肉苁蓉对正常大鼠有不利影响:自然增重减慢(P<0.01),血清 T_3下降(P<0.05),rT_3及 TRH 升高(P<0.01),TSH 有上升趋势。这些变化可能是中药影响甲状腺激素外周代谢的结果。可用进退给药法加以避免。提出:无虚之机体一般不宜用大量助阳药,若要用可试用进退,法。
Large dose of Yang(阳)-restoring herb medicines(Radix Codonopsis Pilosulae,Astragalus membranaceus,Radix Aconiti Praeparata,Epimedium brevicornum,Cortex Cinnamomi and Herba Cistanchis)may exert an unfavorable effect on normal rats,i.e:natural weight gain reduced(P< 0.01),serum T_3 decreased(P<0.05),rT_3,TRH levels raised(P<0.01)and TSH showed a raising tendency.Lower T_3 and higher rT_3 levels may be the effects of Yang-restoring herb medicines on the peripheral metabolism of thyroid hormones,i.e.more thyroxine was degraded to rT_3 with little biological effect and less was transformed to T_3 with strong hormonal effect.This unfavorable effect,however,can be avoided by Forward-Backward method.It was advised that large dose of Yang-restoring herb medicines could not be given to the organisms without symptoms of Yang deficiency.If it were tried to do so,Forward.Backward method might be recommended.
