多层螺旋CT灌注对脑胶质瘤分级的初步研究

A pilot study of the multislice spiral CT perfusion in cerebral glioma

目的:探讨CT灌注在胶质瘤术前分级中的作用。方法:19例经手术病理证实的脑胶质瘤病例术前接受CT灌注检查。根据病理,将病例分为低级别(n=9)和高级别(n=10)两组进行分析。获得肿瘤血流灌注的时间-密度曲线及灌注参数并进行相关性统计学分析。结果:低、高级别胶质瘤的脑血容量(CBV)、血管表面通透性(PS)均数±标准差分别为4.00±2.30、8.30±6.44、0.42±0.26和13.65±6.21,组间差异有统计学意义(P<0.05)。结论:脑CT灌注测量可以反映不同级别胶质瘤的血流灌注状况,从而为胶质瘤术前分级提供有价值的信息。

Objective To analyze the value of the multisliee spiral CT perfusion in the evaluation of glioma grade. Methods Nineteen patients with gliomas eonfirmed by pathology underwent the conventional MR and the multislice CT perfusion imaging preoperatively. According to the pathological findings, all the eases were divided into low-grade group （n=9） and high-grade group （n=10） . The CT data were transferred to the on-line working station and were then processed to obtain the time-signal curves and the color perfusion maps. The perfusion parameters, including the cerebral blood volume （CBV）, the cerebral blood flow （CBF）, the mean transit time （MTT） and the permeability of surfaces （PS） in tumoral parenehyma, were caleulated. Results There lied significant difference in the mean CBV and PS between the low-grade group and the high-grade group （4.00±2.30 vs 0.42±0.26 and 8.30±6.44 vs 13.65±6.21, respectively, P〈0.05）. Conclusions The multisliee spiral CT perfusion may reflect the blood flow in glioma, which might provide some valuable information for preoperative glioma grading.