丹参、川芎嗪对油酸型呼吸窘迫综合征预防作用的实验研究

Prophylactic Effects of Salvia miltiorrhizae and Ligustrazine on Experimental Respiratory Distress Syndrome Indueed by Oleic Acid in Rats

本文观察了丹参,川芎嗪对油酸型呼吸窘迫综合征的预防作用,并与地塞米松的预防作用进行了比较。结果显示丹参、川芎嗪均可以减轻油酸所致的某些肺部病变和肺系数下降。与地塞米松的预防效果相似。认为早期预防性应用丹参、川芎嗪可以减轻或预防 RDS 的发生。

The prophylactic effects of Salvia miltiorrhizae and ligustrazine on experimental respiratory distress syndrome(RDS)in Wistar rats were observed and compared with the dexamethasone. Sixty-two male rats weighing 194.68±20.40 g(M±SD)were used in this experiment.The rats were randomly divided into five(A～E)groups.Group A was given normal saline 0.1 ml/kg alone and group B oleic acid 0.1 ml/kg;both were injected in tail vein.and the latter produced typical RDS.Group C,D,E were injected intraperitoneally with agents of dexamethasone 2 mg/kg,Salvia miltiorrhizae 1.5 g/kg,and ligustrazine 20mg/kg,respectively,15 minutes before oleic acid intravenous injection. All of the animals were sacrificed quickly 6 hours after injections and lung tissues were taken and examined with light and electronic microscope.The results showed that all of these medicines could minimize the lesions caused by oleic acid.Lung/body index was reduced.Prophylactic effects of Salvia milliorrhizae and ligustrazine were similar to dexamethasone.The authors considered that preventive use of Salvia miltiorrhizae or ligustrazine could protect the lung from the development of RDS.