时域光声谱技术及其在生物组织检测中的应用

Time-Resolved Optoacoustic Technique and Its Applications to Noninvasive Monitoring of Biological Tissue

当强度调制的光束照射于吸收物质,周期性热流使周围的介质热胀冷缩而激发声波,这种将光能转化为声能的现象称为光声效应。基于光声效应的时域光声谱技术将光学和声学有机地结合,为生物组织的无损检测技术提供了新的检测手段。该技术能够实现类似光学技术的高对比度和近似于声学技术的高精度和穿透深度,在生物医学检测中具有广阔的应用前景。文章介绍时域光声谱技术的原理及其在生物组织成分检测和层析成像检测中的应用。

Time-resolved optoacoustic technique offers a new ingredient in noninvasive monitoring of biological tissues. Due to the heterogeneous property of biotissue, different level of optical energy depositions generates different strength of the acoustic signal across the tissue. This makes it possible to probe the functional information tomographically inside the biological tissue. It becomes increasingly attractive as a hybrid non-invasive monitoring technique because it takes the advantages of high contrast feature delivered by the optical techniques and high penetration depth and resolution offered by the acoustical techniques. After a brief introduction of its theory, this paper reviews the state-of-the-art time-resolved optoacoustic methods that have been successfully applied in biomedicine, with a concentration on analytical monitoring and tomography.