核素显像诊断肝细胞腺瘤的价值探讨

The Diagnostic Value of Radionuclide Imaging in Hepatic Adenoma

目的:探讨99Tcm-SC和99Tcm-EHIDA联合显像诊断肝细胞腺瘤(HA)的显像特点及临床价值。方法:8例HA行核素显像,首次为99Tcm-SC显像,隔日行99Tcm-EHIDA显像,应用兴趣区技术分别计算30min、1h和2h的病灶/正常肝组织(L/N)比值。同时与CT和MRI检查结果比较。结果:全部病人皆行外科手术治疗并经病理学确诊。核素显像诊断HA准确率100%(8/8),高于CT和MRI检查准确率(4/7,5/6)。核素显像30min、1h和2h的L/N比值差异有统计学意义。结论:核素显像是诊断HA可靠而有效的方法,尤其当CT和MRI缺乏典型表现时,有其独到的应用价值。

Objective：To evaluate the accuracy and characteristics of combined use of ^99Tc^m-sulfur colloid （SC） and ^99Tc^m-diethyliminodiacetic acid （EHIDA） imaging on the diagnosis of hepatic adenoma （HA）. Methods： 8 patients with HA were involved in this study.All of them were studied by nuclear medicine （NM） with dual-radiopharmaceuticals.The ^99Tc^m-SC imaging was perfomed first ,then the ^99Tc^m-EHIDA imaging two days later,and the ratios between lesions and normal liver tissue（L/N） were calculated in terms of different counts within the same size regions of interest （ROI） in different phases （30min ,1h and 2h respectively）. Some of the cases were also analysed by CT and/or MRI within one week before the operations .Sesults：All of the cases were submitted to surgical treatment and confirmed diagnosis of HA by pathology.For HA,scintigrahy presented a accuracy of 100%（8/8）,which was higher than that of CT and MRI comparatively.For ^99Tc^m-EHIDA imaging ,there were significant differences in L/N ratios among different phases（30min ,1h and 2h ）.Conclusion： The results show that radionuclide imaging proved to be a safe,invasive and effcetive mehtod on the diagnosis and differential diagnosis of HA,especially,when CT and /of MRI findings are not typical.