茵栀黄对动物高间接胆红素血症的胆红素排泄作用

Effect of Yin Zhi Huang on Bilirubin Excretion in Animals with Unconjugated Hyperbilirubinemia

兔灌胃茵栀黄3天,可加速注入的非结合胆红素自血浆排泄;苯巴比妥灌胃3天可产生类似的作用,但较弱。给大白鼠腹腔内注射茵栀黄或苯巴比妥3天,并结扎其胆总管,茵栀黄或苯巴比妥处理的动物其间接胆红素水平较对照组为低,而肝胆红素含量和血浆直接胆红素水平增高。提示菌栀黄和苯巴比妥具有相同的降低血清间接胆红素的作用。

Yin Zhi Huang(YZH)given stomach perfusion daily for three days in rabbits accelerated plasma clearance of infused unconjugated bilirubin.A similar but less dramatic effect could be obtained by using YZH or phenobarbital i.p.daily for three days in rats employing simultaneously with the method of bile duct ligation,plasma indirect bilirubin levels was lower but hepatic bilirubin content and plasma direct bilirubin levels were higher in both YZH and phenobarbital treated rats than those in the control animals.These observations suggested that YZH and phenobarbital shared a common mechanism of acting in lowering the indirect bilirubin levels of serum.