亚低温治疗重型颅脑损伤的疗效研究

Effect of mild hypothermia therapy on patients with severe brain injury

目的:观察亚低温治疗重型颅脑损伤(SBI)的临床效果。方法:55例SBI患者,随机分成亚低温组(28例),对照组(27例),治疗期间监测患者并发症发生情况;在伤后6个月根据GCS评分判定预后,结果分为良好、轻残、重残、植物生存与死亡。结果:在发病后1周内,上消化道出血发生率亚低温组为39.29%、对照组为81.48%(P<0.005),外伤后癫痫发生率亚低温组为21.43%、对照组为48.15%(P<0.05),两组比较均有显著性差异。恢复良好者在亚低温组为46.43%、对照组为18.52%,亚低温组的病死率为21.43%、对照组为48.12%,两者差异均有显著性(P<0.05)。结论:亚低温治疗有利于降低SBI病死率,改善患者预后。

Objective：To observe the effect of mild hypothermia in treatment of severe brain injttry（SBI）Methods：A total of 55 patients with SBI were randomly divided into mild hypothemaia group（ n = 28） and control group（ n = 27）. The occurrence of complications was monitored during the therapy. 6 months later; the prognosis of the patients was evaluated according to the standard of COS which was classified as good, light disablement,heavy disablement, plant existence and deaths. Results： The occurrence of upper gastrointestinal hemorrhage was 39.29 % in the mild hypothermia group, and 81.48 % in the control group（ P 〈 0. 005） .The morbidity of epilepsy was 21.43% and 48.15% in the mild hypothermia group and the control group respectively （ P 〈 0.05） .The difference was significant. In the mild hypothermia group,good results were found in 46.43% of the patients,with a mortality of 21.43% ;in the control group,good results were observed in 18.52% of the patients,with a mortality of 48.12% （ P 〈 0.05 respectively）. Conclusion：The data show that the therapy of the mild hypothermia can reduce the occurrence rate of upper gastrointestinal hemorrhage and epilepsy, and can reduce mortality of oatients with SBI, and imorove prognosis of them.