慢性萎缩性胃炎寒热辨证与舌苔脱落细胞结构变化的关系

Changes in Microstructure and Ultrastructure Between Differentiation of Cold and Heat Syndrome in Chronic Atrophied Gastritis and Exfoliative Cells of Fur

应用光镜与电镜技术对慢性萎缩性胃炎(CAG)寒热不同证候患者56例舌苔脱落细胞进行观察。光镜发现 CAG 寒证组患者舌苔角化细胞水平低于 CAG 热证组(P<0.01),而角化前细胞水平则明显高于热证组(P<0.01)。寒热两证患者舌苔完全角化细胞水平和异常角化细胞水平无明显差异(P>0.05);舌苔渗出炎性细胞不同种类构成比有显著差异(P<0.05)。电镜观察结果,CAG 热证组患者舌苔角化前细胞出现纤维化改变,细胞间桥粒已消失,胞核出现异染质;寒证组患者舌苔角化前细胞纤维化改变不明显,细胞间仍以指状突起相连。寒热两证中均有细菌存在。CAG 寒热两证患者舌苔脱落细胞的改变可能为其早期辨证诊断提供微观化指标。

In this paper,exfoliative cells of fur in 56 cases of chronic atrophidd gastritis(CAG)with Cold or Heat syndrome was observed by means of microscopy and electron microscopy.With microscopy, the authors found that keratinization of epithelial cells of fur in Cold syndrome group of CAG were markedly fewer than those in Heat syndrome group(P<0.01);while pre-keratinization cells were much more than those in Heat syndrome group(P<0.01);the constituent ratio-of complete keratin- ization cells of fur in the two groups were markedly different.With the elecroscopy,fibrosis changes was appeared in pre-keratinization cells of Cold syndrome patients with CAG;demosome was disappeared;metachromasia was appeared in nucleus;fibrosis change in Heat syndrome group was not obvious.Cells were still joined to one another by fingered protrusion.There were baeterias in both Cold and Heat syndrome groups.The change of exfoliative cells of fur in Cold and Heat syndromes in CAG,probably,can offer us a microcosmic sign for its early differentiation or diagnosis.