健脾灵片治疗脾虚腹泻的临床与实验研究

Clinical Observation and Experimental Study on Treatment of Diarrhea Due to Spleen Deficiency with Jianpiling

本文报道用中药健脾灵片治疗脾虚腹泻268例,治愈率63.4%,总有效率98.5%。西药对照组75例,治愈率38.7%,总有效率94.7%,两组治愈率比较有非常显著差异(P<0.001)。实验研究表明,本方能增加小肠吸收功能,对兔离休空肠、回肠蠕动有明显抑制作用。

The climical and experimental results of Jianpiling for treating diarrhea due to Spleen deficiency were reported in this paper.268 cases in the treatment group were treated with Jianpiling,8 tablets three times daily for a consecutive period of 40～60 days.The curative rate and the total effective rate were 63.4% and 98.5% respectively.75 cases in the control group were treated with SASP or Diphenoxylatum Co.,the curative rate and the total effective rate being 38.7% and 94.7% respective- ly.The difference of the curative rate between the two groups was statistically significant(P<0.001). The excretory rate of D-xylose demonstrated that Jianpiling could increase the resorptive function of small intestine.The experiment on isolated small intestine of rabbits showed that Jianpiting could strikingly inhibit the peristalsis of isolated jejunum and ileum.The effect of relieving spasm of the intestine and alleviating pain was taken by antagonising the exictative function of M-regeptor for acetylcholine and directly inhibiting the intestinal smooth muscle.