抗癌药对黑胸大蠊淋巴细胞和生殖细胞核结构的损伤

Effect of Anticancer Drugs on Nuclear Damage in Lymphocytes and Germ Cells of Periplaneta fulginosa

噻替派浓度为0．1％、0．3％、0．5％时，黑胸大蠊精母细胞染色体断裂和裂隙率分别为6．3％、10．5％和14．2％，显著地高于对卵母细胞的影响；和雄虫外周血淋巴细胞微核率呈平行关系，随微核率增多而增加。5－氟尿嘧啶浓度为0．1％、0．3％和0．5％时，卵母细胞染色体断裂和裂隙率分别为3．5％、9．8％和16．2％，和雌虫外周血淋巴细胞微核率呈平行关系，随微核率增多而增加，而对雄虫生殖细胞影响不显著。

0.1%, 0.3%, 0.5%Thio-TEPA induced 6.3%, 10.5% and 14.2% chromosome break or gap in spermatocyte of coockroach respectively. This was markedly higher than those in oocyte. In doses from 0.1 to 0.5 Tho-TEPA the frequency of micronucleus increased parallely with nuclear damage.0.1 %, 0.3%,0.5% 5-fluorouracil induced 3.5%, 9.8%, 16.2% chromosome break or gap in oocytes respectively. This was paralled with the frequency of micronllcleus in lymphocytes of the female. 5-fluorouracil showed not marked effect on spermatocyte.