摘要
氨基糖甙类抗生素所致的中毒性耳聋为小儿耳聋的重要原因。采用补肾活血通窍方治疗30例患儿,结果63.3%的患儿听力得到改善。动物实验证实该方药能预防氨基糖甙类抗生素对内耳柯替氏器毛细胞的损害,保护动物的听力。
This paper reports 30 cases of hearing-loss induced by aminoglycosid antibiotic ototoxicity treated mainly with Kidney-tonifying herbs such as Herba Epimedii,Rhizoma Drynariae,Rhizoma Polygonati,Radix Polygoni Multiflori,Magnetitum and Rhizoma Acori Graminei,etc.After three month's treatment,the authors found that 19 cases had improved their hearing more than 15 db, among which there are 8 cases who had improved 15 db and 11 cases 30 db.The patients'hearing of pre-treatment and post-treatment were determined by BAR V-wave hearing threshold. In order to further prove that Kidney-tonifying prescription can antagonize the aminoglycosid antibiotic ototoxicity,animal exp.eriments had been made.The authors chose guinea pigs for experimental animals,which were randomly divided into three groups:Kanamycin group,kanamycin with Kidney-tonifying herbs group,and control group.The indexes of the experiments were the animals'helix reflection index,BAR and observation of animals'cochlear under electronmicroscope. As a result,the damage to hair cell of Cortis organ has marked for the animals of kanamycin group, while for kayamycin with herbs group,it was obviously slighter(P<0.01).There was significant difference between the groups.The result indicates that Kidney-tonifying herbs had the effect of protecting the animals'hair cells of cortis organ against aminoglycosid antibiotic ototoxicity and thus protected the animals'hearing.
