半夏对大白鼠妊娠及胚胎的毒性研究

Studies on the Pregnancy and Embryotoxicity of Rhizoma Pinelliae in Rats

半夏对大白鼠妊娠和胚胎的毒性试验表明:生半夏粉9 g/kg 灌胃,对妊娠母鼠和胚胎均有非常显著的毒性,而相同剂量的制半夏粉与对照组无明显的差异,但是制半夏汤剂30g/kg(相当于临床常用量的150倍)则能引起孕鼠阴道出血,胚胎早期死亡数增加,胎儿体重显著降低,提示前人所谓"半夏动胎"是有其道理的生半夏汤剂30g/kg 对大白鼠妊娠和胚胎的毒性与制半夏汤剂无差异,说明半夏汤剂的毒性不因炮制而降低。

This experiment was conducted with sexually mature,virgin female rats.The body weight of the female rats Was 230～350 g,that of male rats was 300～400 g.The female and male rats were mated overaight(the ratio was 3:1),the pregnant rats were divided into 7 groups.All drugs were glven p.o.from the 6th to the 15th days of gestation.Pregnant rats were weighted on the 0th,6th, 10th,13th and 16th days of gestation.Vaginal bleeding of pregnant rats was examined on the 8th, 10th,12th,14th and 16th days of gestation. The rats were killed on the 20th day of gestation so as to count the number of implantation,dead and living fetuses.The living fetuses of rats were removes,weighted and inspected for gross abnormalities;the internal and skeletal malformations of live fetuses were examined. The following results were obtained:9 g/kg dose of the crude Rhizoma Pineiliae powder was feund to have the action in increasing the number of pregnant individuals with vaginal bleeding and dead ernbryo-signifficantly.Comparing with the control,9 g/kg dose of the powder of processed Rhizoma Pinelliae did not show any toxicity.But 30 g/kg dose of the decoction of processed or crude Rhizorna Pinelliae was found to increase the number of pregnant individuals with vaginal bleeding and dead embryosignificantly. The project supported by National Natural Science Foundation of China