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基质金属蛋白酶-9与食管癌转移 被引量：3

Matrix Metalloproteianse 9 and Metastasis of Esophageal Cancer
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摘要 目的探讨基质金属蛋白酶-9(MMP-9)与食管癌转移之间的关系。方法采用酶联免疫吸附实验(ELISA)检测MMP-9的含量。结果MMP-9在淋巴结转移的食管癌患者血清中的含量为(812.34±92.67)μg/ml,在无淋巴转移的食管癌患者血清中的含量为(734.53±75.36)μg/ml,正常对照组为(418.53±77.31)μg/ml。MMP-9在淋巴结转移的食管癌患者血清中的含量显著高于无淋巴结转移的食管癌患者。MMP-9在食管癌患者(无论有无淋巴结转移)血清中的含量均显著高于正常对照组(P<0.05)。结论MMP-9在食管癌的转移过程中发挥着重要作用。 Objective To study the effect of MMP-9 in the metastasis of esophageal canc er. Methods The MMP - 9 serum level was measured by enzyme- linked immunosorbent assay （ELISA）. Results The MMp - 9 serum level in esophageal cancer patients without lymphoma node metastasis was （812.34 ±92.67 ）μg/ml and the MMP- 9 serum level in esophageal cancer patients without lymphoma node metastasis was （734.53 ± 75.36） μg/ml. The MMP - 9 serum level in normal subjects was （418.53 ± 77.31 ） μg/ml. The MMP - 9level in the serum of patients with or without lymphoid node metastasis was higher than that of normal subjects significantly （ P 〈0. 05 ）. The MMP - 9 level in serum of esophaheal cancer patients with lymphoid node metastasis was higher than that of esophageal patients without lymphoid node metastasis （ P 〈 0. 05 ）. Conclusion MMP - 9 is concerned with the metastasis of esophagus cancer.
作者 刘威 秦凤玲 赵琪
机构地区 河南省安阳市肿瘤医院 河南大学淮河医院
出处 《医药论坛杂志》 2005年第17期38-39,共2页 Journal of Medical Forum
关键词 基质金属蛋白酶 食管癌 酶联免疫吸附实验 Matrix metalloproteinase Esophageal cancer Enzyme - linked immunosorbent assay
分类号 R735.1 [医药卫生—肿瘤]
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  • 1Ramos DeSimone N, Hahn Dantona E,Sipley J, et al. Activation of matrix metalloproteinase-9(MMP-9) via a converging plasmin / stromelysin-1 cascade enhances tumor cell invasion[J]. J Biol Chem, 1999,274(19) : 13066.
  • 2Sato F, Shimada Y, Watanabe G, et al. Expression of vascular endothelial growth factor, matrix metalloproteinase-9 and E-cadherin in the process of lymph node metastasis in oemphageal cancer[J ]. Br J Cancer, 1999,80(9) : 1366.
  • 3Frederiok J, Bhada S, Subbiah M, et al. Multifunctional role for fetuin (fetal protein) in lipid transport [J]. Faseb J, 1991,5(7) :2145.
  • 4Saito K, Takeha S, Shiba K ,et al. Clinicopathologic significance of urokinase receptor and MMPS-9 positive stromal cells in human colorectal cancer: functional multiplicity of matrix degradation on hematogenous matastasis[J]. Int J Cancer, 2000,86( 1 ) :24.
  • 5Chambers AF,Matrisian LM. Changing views of the role of matrix metalloproteinases in metastasis[J]. Natl Cancer Inst, 1997,89(4) : 1260.
  • 6Chesler L, Golde DW, Bersch N, et al. Metalloproteinase inhibition and erythroid potentiation are independent activities of tissue inhibitor of metalloproteinases-1 [J]. Blood, 1995, 86: 4506-4515.
  • 7Aznavoorian S, Murphy AN, Stetler Stevenson WG, et al. Molecular aspects of tumor cell invasion and metastasis [J]. Cancer, 1993, 71:1368-1383.
  • 8Ramos DeSimone N, Hahn Dantona E, Sipley J, et al. Activation of matrix metalloproteinase-9 (MMP-9) via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasion [J]. J Biol Chem, 1999, 274(19):13066-13076.
  • 9Goldverg GJ, Strongin A, Collier IE, et al. Interaction of 92 kDa type Ⅳ collagenase with tissue inhibitor of metalloproteinases prevents dimerization, complex formation with interstitial collagenase and activation of proenzyme with stromelysin [J]. J Biol Chem, 1992, 267:4583-4591.
  • 10Watanabe M, Takahashi Y, Ohta T, et al. Inhibition of metastasis in human gastric cancer cells transfected with tissue inhibitor of metalloproteinase 1 gene in nude mice [J]. Cancer 1996, 77:1676-1680.

共引文献71

同被引文献17

  • 1王宪远,何炜,许迎朝.基质金属蛋白酶-9与食管鳞癌预后的关系[J].河南医学研究,2005,14(3):235-236. 被引量：6
  • 2张志超,孙亚欣,贾明库.基质金属蛋白酶含量及表达与肝细胞癌侵袭转移的关系[J].吉林大学学报（医学版）,2006,32(1):116-118. 被引量：4
  • 3Clark EA, Gohb TR, Lander ES, et al. Genomic analysis of metastasis reveals an essential role for RhoG [J]. Nature, 2000, 406 (6840): 532-535.
  • 4Kjeldsen L, Johnsen AH, Sengelov H, et al. Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase [J]. Biol Chem, 1993, 268 ( 14 ) :10425-10432.
  • 5Sousa MM, do Amaral JB, Guimaraes A, et al. Up-regulation of the extracellular matrix remodeling genes, biglycan, neutrophil gelatinase-associated lipocalin, and matrix metalloproteinase-9 in familial amyloid polyneuropathy[ J]. FASEB J, 2005, 19 ( 1 ) : 124-126.
  • 6Ohashi K, Nemoto T, Nakamura K, et al. Increased expression of matrix metalloproteinase 7 and 9 and membrane type 1-matrix metalloproteinase in esophageal squamous cell carcinomas [ J ]. Cancer, 2000, 88(10) : 2201-2209.
  • 7Tanioka Y, Yoshida T, Yagawa T, et al. Matrix metalloproteinase-7 and matrix metalloproteinase-9 are associated with unfavourable prognosis in superficial oesophageal cancer[J]. BrJ Cancer, 2003, 89(11) : 2116-2121.
  • 8Yan L, Borregaard N, Kjeldsen L, et al. The high molecular weight urinary matrix metalloproteinase (MMP) activity is a complex of gelatinase B/MMP-9 and neutrophil gelatinase-associated lipocalin (NGAL). Modulation of MMP-9 activity by NGAL[ J]. J Biol Chem, 2001, 276(40) :37258-37265.
  • 9Kubben FJ, Sier CF, Hawinkels LJ, et al. Clinical evidence for a protective role of lipocalin-2 against MMP-9 autodegradation and the impact for gastric cancer[ J]. Eur J Cancer, 2007, 43 (12) :1869-1876.
  • 10Zhang XF, Zhang Y, Zhang XH, et al. Clinical significance of NGAL mRNA expression in human rectal cancer[ J]. BMC Cancer, 2009, 9(1) : 134.

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医药论坛杂志
2005年 第17期

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