COX-2、VEGF在子宫内膜癌中的表达及意义

Expression and significance of cyclooxygenase-2 and vascular endothlial cell growth factor in endometrial carcinoma

目的探讨环氧化酶-2(COX-2)和血管内皮生长因子(VEGF)在子宫内膜癌发生发展中的作用。方法采用免疫组化SP法检测41例子宫内膜癌和15例正常子宫内膜组织中COX-2、VEGF的表达。结果子宫内膜癌组织中COX-2、VEGF的阳性表达率明显高于正常子宫内膜组织(P均<0.05,);低分化和肌层浸润>1/2者的子宫内膜癌组织中COX-2表达明显高于中、高分化和肌层浸润≤1/2(P<0.05)者;COX-2表达阳性的子宫内膜癌,其VEGF阳性率明显高于COX-2表达阴性者(P<0.05)。结论COX-2在子宫内膜癌组织中呈高表达,并可上调VEGF的表达,二者可能与子宫内膜癌的发生发展有关。

Objective： To investigate the effect of cyclooxygenase-2 （COX-2）and vascular endothelial cell growth factor（VEGF）in endometrial carcinoma. Method：The expression of COX-2 and VEGF were examined by immunohistochemistry SP method in 41 cases of endometrial carcinoma and 15 cases of normal endometrium. Results： The expression of COX-2, VEGF was significantly higher in endometrial carcinoma than in normal endometrium （P〈0. 05）. Overexpression of COX-2 in endometrial carcinoma was related to differentiation degree and depth of invasion （P〈0. 05）, but had no relation to FIGO staging（ P 〉0.05）. The expression of VEGF was significantly higher in cases whose COX-2 expressed positively than COX-2 expressed negatively（ P〈0. 05）. Conclusion：COX-2 and VEGF are closely related with carcinogenesis and development of endometrial carcinoma. COX-2 may induce the expression of VEGF.