宫颈癌术前新辅助化疗20例疗效观察

An Observation on Curative Effect of 20 Cases of Pre-operation Neoadjuvant Chemotherapy for Bulky Cervical Carcinoma

目的:研究巨块型宫颈癌术前新辅助化疗(neoadjuvantchemotherapy,NACT)的疗效。方法:2000年1月～2004年2月收治的巨块型宫颈癌20例,采用化疗方案为:顺铂(DDP)20mg/m2,静点,第1～5天;博莱霉素(BLM)10mg/m2,肌注或静点,第1、3、5天;羟基喜树碱(HCPT)6～10mg,静点,第1～5天。化疗后19例行广泛全子宫加盆腔淋巴结清扫术。结果:本组20例巨块型宫颈癌应用NACT治疗,显效率(CR+PR)70%,有效率(CR+PR+MR)95%。其中2例局部肿物基本消失,宫颈仅呈糜烂状,效果甚为理想。结论:术前采用DDP+BLM+HCPT方案化疗,可使宫颈局部肿块缩小或消失,从而提高手术成功率,延长患者的生存期。

Objective： To study the observation on the curative effect of pre-operation neoadjuvant chemotherapy for bulky cervical carcinoma. Methods： A total of 20 cases with bulky cervical carcinoma were treated during January 2000 to February 2004. The chemotherapy adopted was DDP 20mg/ m^2 intravenous injection from 1st to 5th day; BLM 10mg/m^2 muscle or intravenous injection at 1st, 3rd and 5th day; HCPT 6-10mg intravenous injection from 1st to 5th day. After chemotherapy, 19 cases were treated with radical surgery. Results： The 20 cases of bulky cervical carcinoma were treated with NACT, the CR＋PR was 70%, CR＋PR＋Impr was 95%. Two cases of them had an ideal effect, the partial tumor was basically eliminated, and only with cervical corruption. Conclusion： Before operation, the chemotherapy plan DDP＋BLM＋HCPT is adopted, which can reduce or eliminate partial cervical tumors, thus can increase success rate of operation, and can extend the survival period of patients.