摘要
TGF-β(transforming growth factor beta,转化生长因子β)是一种多功能的多肽类细胞因子,在调节细胞的生长和分化中起重要作用。目前,鉴定并命名了三种TGF-β受体(TβR)的亚型:TβR-Ⅰ、TβR-Ⅱ、TβR-Ⅲ。TGF-β与TβR(属丝氨酸和苏氨酸激酶受体家族)结合通过Smad蛋白介导的信号通路发挥生物学功能。近年来的研究结果证实TGF-β及其受体与肿瘤的发生、发展密切相关。在许多肿瘤如结肠癌、胰腺癌中发现TβR的突变。TGF-β对肿瘤的作用是多样的,在肿瘤发生的早期可作为抑癌基因抑制细胞的增殖和分化,但在肿瘤的进展期则可抑制免疫功能、增加血管的生成、诱导细胞外基质的产生而促进肿瘤的侵袭和转移。
TGF-beta （transtforming growth factor-beta） is a multifunctional cytokine that regulates growth and differentiation of various types of cells. There are 3 subtypes of TGF- beta receptor, including TβR-Ⅰ, TβR- Ⅱ ＋and TβR- Ⅲ. TGF- beta binds to TβR-Ⅰand TβR- Ⅱ （serine/threonine kinase receptors）, which mediates intracellular signals through Smad proteins. Recent findings demonstrate that the TGF-beta and its receptor are assoceated with tumor. Somatic mutations of TβR have been demonstrated in several different tumor types, including colorectal cancers and pancreatic caners. The effect of TGF-beta in turner is complex, TGF-beta is considered as a tumor suppressor gene in early tumor and growth inhibition by the TGF-beta has been extensively studied in many cell types. However, TGF-beta can enhance growth in progressive tumor and possible mechanisms for these growth enhancing effects, including the induced immunosuppression, enhanced angiogenesis, and increased peritumoral stroma formation.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2005年第17期1016-1020,共5页
Chinese Journal of Clinical Oncology
