摘要
目的:探讨甘肃汉族人群中白血病的易感性与HLA基因多态性之间的关联。方法:采用序列特异性寡核苷酸探针杂交技术(PCR-SSO),对57例白血病患者和45例健康对照组进行HLA-A、-B及-DRB1基因分型。结果:在等位基因HLA-A、-B及-DRB1中,白血病患者的HLA-A01、-B38及-DR15基因的基因频率高于正常对照组(P<0.05),而HLA-A11及-DR03基因的基因频率明显下降(P<0.05)。结论:甘肃省汉族人群基因HLA-A01、-B38及-DR15对白血病具有遗传易感作用;而基因HLA-A11和-DR03对白血病具有遗传拮抗作用。
AIM: To explore the correlation between the polymorphism of HLA-A. -B and -DRB1 alleles and susceptibility to leukemia in Chinese Han population, Gansu province. METHODS: The polymorphism of HLA-A, -B and -DRB1 alleles in 57 patients with leukemia and 45 normal controls were determined by PCR with sequence-specific oligonucleotide probe (PCR-SSO). RESULTS: The frequencies of allele HLA-A01, -B38. and -DR15 in patients with leukemia were higher than those in control group ( P 〈 0. 05 ), while the frequencies of allele HLA-A11 and -DR03 notably decreased ( P 〈 0.05). CONCLUSION : HLA-A01. -B38 and -DR15 alleles in Han population, Gansu province seem to contribute to the genetic susceptibility, while HLA-A11 and -DR03 alleles to the genetic resistance, to leukemia.
出处
《细胞与分子免疫学杂志》
CAS
CSCD
北大核心
2005年第5期619-621,共3页
Chinese Journal of Cellular and Molecular Immunology
基金
甘肃省自然科学基金暨中青年基金项目(No.YS001-A23-020)