HLA-A,-B及-DRB1等位基因的多态性与白血病易感性的关联

Correlation between the polymorphism of HLA-A,-B,and -DRB1 alleles and susceptibility to leukemia

目的:探讨甘肃汉族人群中白血病的易感性与HLA基因多态性之间的关联。方法:采用序列特异性寡核苷酸探针杂交技术(PCR-SSO),对57例白血病患者和45例健康对照组进行HLA-A、-B及-DRB1基因分型。结果:在等位基因HLA-A、-B及-DRB1中,白血病患者的HLA-A01、-B38及-DR15基因的基因频率高于正常对照组(P<0.05),而HLA-A11及-DR03基因的基因频率明显下降(P<0.05)。结论:甘肃省汉族人群基因HLA-A01、-B38及-DR15对白血病具有遗传易感作用;而基因HLA-A11和-DR03对白血病具有遗传拮抗作用。

AIM： To explore the correlation between the polymorphism of HLA-A. -B and -DRB1 alleles and susceptibility to leukemia in Chinese Han population, Gansu province. METHODS： The polymorphism of HLA-A, -B and -DRB1 alleles in 57 patients with leukemia and 45 normal controls were determined by PCR with sequence-specific oligonucleotide probe （PCR-SSO）. RESULTS： The frequencies of allele HLA-A01, -B38. and -DR15 in patients with leukemia were higher than those in control group （ P 〈 0. 05 ）, while the frequencies of allele HLA-A11 and -DR03 notably decreased （ P 〈 0.05）. CONCLUSION ： HLA-A01. -B38 and -DR15 alleles in Han population, Gansu province seem to contribute to the genetic susceptibility, while HLA-A11 and -DR03 alleles to the genetic resistance, to leukemia.