PCNA、P21和COX-2在尖锐湿疣中的表达及其意义

The expressions of PCNA, P21 and COX-2 in condyloma accuminatum and its significance

目的:研究尖锐湿疣组织中增殖细胞核抗原(PCNA)、P21及环氧化酶-2(COX-2)蛋白表达及其意义。方法:应用免疫组化SP法对30例尖锐湿疣组织及10例正常组织中PCNA、P21及COX-2蛋白进行检测。结果:30例尖锐湿疣组织中PCNA、P21阳性表达较正常对照组有不同程度的增加,有统计学意义;COX-2蛋白在尖锐湿疣组织中阳性表达率13.3%(4/30),正常组织无阳性表达(0/10),两者之间无显著性差异(P>0.05);尖锐湿疣组织中PCNA与P21表达之间无相关性(r=0.196,P>0.05)。结论:PCNA、P21过表达与尖锐湿疣角质形成细胞自限性增殖密切相关。

Objective： To determine the expression of PCNA, P21 and COX - 2 in condyloma accuminatum （CA） and its significance. Methods： lmmunohistochemical method was adopted to measure the expressions of PCNA, P21 and COX - 2 in 30 cases of CA anti the normal control tissues of 10 CA cases. Results： The expressions of PCNA, P21 in the skin lesion of CA were signifieantly higher than that in the normal controls; the positivity rate of COX - 2 was 13.3% in CA tissues and no COX - 2 positive cells were found in the normal controls （ P 〉 0.05）. Furthermore, the expression of PCNA was not correlated with P21 protein expression. Conclusion： The over expression of PCNA and P21 are closely related to the self- limited proliferation of keratinoeytes in CA.