急性细菌性脑膜炎患儿脑脊液中CXCL-5测定

Detection of CXCL-5 in the cerebrospinal fluid in children with acute bacterial meningitis

目的:探讨急性细菌性脑膜炎患儿脑脊液和外周血中CXCL-5水平及其在疾病发生发展中的作用。方法:采集34名小儿急性细菌性脑膜炎患者和24例非急性细菌性脑膜炎儿童(对照组)脑脊液和外周血标本,利用ELISA方法检测CXCL-5浓度。经合理抗生素治疗,待临床症状控制后,再检测外周血和脑脊液中的CXCL-5含量。结果:急性细菌性脑膜炎患儿脑脊液及外周血血清中CXCL-5水平明显比对照组增高(P<0.001)。经合理抗生素治疗后,急性细菌性脑膜炎患儿脑脊液及外周血血清中CXCL-5水平明显下降(P<0.001)。结论:CXCL-5可能直接刺激中性粒细胞向脑脊液内移动,并参与了脑脊膜炎症过程。

Aim： To measured the levels of CXCL-5 in the cerebrospinal fluid （CSF） and peripheral blood in children with acute bacterial meningitis. Methods ： CSF and peripheral sera were taken from 34 children with acute bacterial meningitis and 24 healthy controls, and CXCL-5 was measured using ELISA method. CXCL-5 in CSF and sera was also detected in these patients after receiving antibiotic treatment. Results： The levels of CXCL-5 in the CSF and sera in children with acute bacterial meningitis were higher than those of healthy controls （ P 〈 0. 001 ） , and decreased significantly after receiving antibiotic treatment （ P 〈0. 001 ）. Conclusion ： CXCL-5 is probably associated with the recruitment of neutrophils into the central nervous system, and plays an important role in the development of meningitis.