慢性心力衰竭患者血清IL-1β、TNF-α水平与左室平均室壁应力测定

Determination of serum IL-1β,TNF-α and left ventricular mean wall stress in patients with chronic heart failure

目的:探讨慢性心力衰竭(CHF)患者血清白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)水平与左室平均室壁应力的关系及临床意义。方法:CHF患者62例,另设15例健康人作对照。血清TNF-α、IL-1β含量测定采用ELISA法。心脏超声测定左室舒张末期和收缩末期内径(Dd和Sd)、室间隔舒张末期和收缩末期内径(IVSd和IVSs),左室后壁舒张末期和收缩末期厚度(PWd和PWs),计算左室平均室壁应力(MWS)。结果:CHF患者血清IL-1β、TNF-α含量及MWS高于对照组;CHF患者血清IL-1β、TNF-α含量与MWS呈正相关(r分别为0.489,0.458,P均(0.001)。结论:CHF患者血清IL-1β、TNF-α含量升高,室壁应力增加,它们可能相互作用,共同参CHF的致病机制。

Aim： To investigate the relationships between levels of serum IL-1β, serum TNF-α, and left ventricular mean wall stress（MWS） in patients with chronic heart failure （CHF）. Methods： Serum IL-1β, and TNF-α were measured using ELISA ,and Dd,Ds, IVSd, IVSs, PWd, and PWs were determined using two-dimensional echocardiography and then MWS was calculated in 62 cases of CHF and 15 normal controls. Results： Serum IL-1β,TNF-α and MWS in the patients with CHF were significantly higher than those in control group. Serum IL-1β and TNF-α were positively correlated with MWS（ r = 0. 489,0458, respectively,P 〈0. 001 ） in patients with CHF. Conclusion ：Serum IL-1β,TNF-α and MWS in the patients with CHF increased,and they may interact and influence each other in the pathogenic mechanism of CHF.