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羟乙基淀粉130/0.4的研究进展 被引量：15

Progresses in the research of hydroxyethyl starch 130/0.4
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摘要 羟乙基淀粉130/0.4是一种新型的羟乙基淀粉代血浆产品,国外已用于临床。重点综述了羟乙基淀粉130/0.4的扩容作用、药动学、安全性评价和临床研究。 The hydroxyethyl starch 130/0.4 （HES 130/0.4） is commonly used as a plasma volume expander in the surgical patients. The review focuses on volume efficacy and safety evaluation, pharmacokinetics and clinical studies of hydroxyethyl starch 130/0.4.
作者 吴翠栓 吴涛
机构地区 北京双鹤药业研究院
出处 《中国新药杂志》 CAS CSCD 北大核心 2005年第8期981-984,共4页 Chinese Journal of New Drugs
关键词 羟乙基淀粉130/0.4 代血浆产品 药动学 安全性评价 hydroxyethyl starch 130/0.4 plasma substitutes pharmacokinetics safety evaluation
分类号 R914 [医药卫生—药物化学] R973.5 [医药卫生—药品]
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参考文献29

  • 1Treib J, Baron JF, Grauer MT, et al. An international view of hydroxyethyl starches[J]. Intensive Care Meal, 1999,25 (3) : 258 -268.
  • 2Jungheinrich C, Sauermann W, Bepperling F, et al. Volume efficacy and reduced influence on measures of coagulation using hydroxyethyl starch 130/0.4 (6%) with an optimised in vivo molecular weight in orthopaedic surgery: a randomised, double-blind study[J]. Drugs R D, 2004,5(1) : 1 - 9.
  • 3Sander O, Reinhart K, Hellmann AM. Equivalence of hydroxyethyl starch HES 130/0.4 and HES 200/0.5 for perioperative volume replacement in major gynaecological surgery [J]. Acta Anaesthesiol Scand,2003,47(9) : 1151 - 1158.
  • 4Treib J, Haass A, Pindur G, ct al. All medium starches are not the same: influence of the degree of hydroxyethyl substitution of hydroxyethyl starch on plasma volume, hemorrheologic conditions,and coagulation[J]. Transfusion, 1996,36(5) :450 - 455.
  • 5Treib J, Haass A, Pindur G, et al. HES 200/0.5 is not HES 200/0.5 Influence of the C2/C6 hydroxyethylation ratio of hydroxyethyl starch(HES) on hemorheology, coagulation and elimination kinetics [J].Thromb Hoemost, 1995,74(6) : 1452 - 1456.
  • 6Waitzinger J, Bepperling F, Pabst G. et al. Effect of a new hydroxyethyl starch(HES) specification(6% HES 130/0.4) on blood and plasma volumes after bleeding in 12 healthy male volunteers[Jj.Clin Drug Invest, 1999,17 ( 2 ) : 119 - 125.
  • 7Waitzinger J, Bepperling F, Pabst G, et al. Pharmacokinetics and tolerability of a new hydroxyethyl starch ( HES ) specification ( 6%HES130/0.4) after single-dose infusion of 6% or 10% solution in heahhy volunteers[J]. Clin Drug Invest, 1998,16(2) : 151 - 160.
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中国新药杂志
2005年 第8期

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