加那索酮的合成

Synthesis of ganaxalone

目的:合成加那索酮。方法:以剑麻皂苷元制得的单烯醇酮醋酸酯为原料,通过6步反应合成目标化合物。结果和结论:目标物经红外光谱、核磁共振氢谱和质谱确证其化学结构,总收率达51.6%。

Objective： To synthesize ganaxalone. Methods： Ganaxalone was synthesized from pregnenolone acetate via six steps. Results： A total yield was 51.6 %. The chemical structure of the target compound was confirmed by IR, ^1H-NMR and MS. Conclusion： Ganaxalone is obtained.