精神分裂症患者长期服用利培酮后体重增加的随访观察

Relationship of long-term treatment with risperdal to weight gain in patients with schizophrenia

目的:探讨精神分裂症患者长期服用利培酮后体重增加的问题.方法:对单一服用利培酮治疗,出院时致体重增加≥3 kg的41例患者进行了为期24个月的跟踪门诊随访.所有患者均每3个月来门诊1次,由原主治医师负责体检、精神检查、心理治疗及指导用药等.数据采用t检验.结果:41例入组患者有10例因病情反复退出研究,实际完成31例.与入院时比较,患者出院后的第6～18个月体重明显增加,其中第9,12个月最为显著(P＜0.01).第21,24个月后体重逐渐回复到入院时的水平(P＞0.05).女性患者体重增加高峰为出院后的6～12个月,而男性是12～15个月.结论:短期服用利培酮后患者体重增加,长期又可逐渐回落到原来水平.

Objective：To evaluate whether long-term treatment with risperdal increases the weight gain in patients with schizophrenia. Methods：41 patients, who were treated with risperdal alone and had weight gains for 3 kg or more when they were discharged from the hospital, were followed up for 24 months. The patients were required to pay an office visit once at three-month intervals to evaluate their physical and mental status and give them psychological consultation and medication guidance. Results： 10 out of the 41 patients were discontinued from the study due to relapsed schizophrenia. The study analyses found that the body weight of patients significantly increased in the period of 6 - 18 months after the discharge, compared with them when they were inhospitalized. The weight gains were reached the most in the 9^th and the 12^th months （ P 〈 0.01 ） . The body weight of patients was back to the same as the one when they were inhospitalized in the 21^th and the 24^th months after the discharge （ P 〉 0.05） . The peak weight gains for female patients occurred between the 6^th and 12^th months after the discharge, while for male patients between the 12^th and the 15^th months. Conclusion：The long-term treatment with risperdal insignificantly increases the body weight in patients with schizophrenia.