口腔梭形细胞鳞癌2例报告

Spindle cell squamous carcinoma of the oral cavity: Report of 2 cases

回顾分析2例口腔梭形细胞鳞癌病例资料,对其临床表现、组织病理学特征、治疗方法及预后等进行讨论。该肿瘤系鳞状细胞癌的变异型,由明确的鳞癌区和具有上皮分化特征的梭形细胞2部分组成,多发于60～70岁男性,好发于下唇、舌和牙龈,临床表现浸润性强,易经淋巴道转移。治疗方法以局部扩大切除加颈淋巴清扫术为主,浸润深度、局部复发和颈淋巴结转移是影响预后的重要指标,患者预后一般较差。

Two cases with spindle cell squamous carcinoma were reported in this paper, The clinical, histopathologic features, therapy anti prognosis were discussed. These tumors probably represented a heterogeneous group of squamous cell carcinoma whose components required either an identifiable squamous cell carcinoma or evidence of epithelial differentiation in the spindle cell. The clinical features were as follow： presents a male predominance among 60 to 70 years and site predilection for the low lip. tongue and gingiva, more aggressive and easy lymphatic metastases. Wide surgical excision, alone or with radical neck dissection was the most successful therapeutic modality. Local recurrence, lymphatic metastases and the depth of tumor invasion into underlying structures were found to be reliable prognostic indicators, the prognosis was dismal.