多形性黄色瘤型星型细胞瘤的诊断与治疗

Diagnosis and treatment of pleomorphic xanthoastrocytoma

目的探讨多形性黄色瘤型星形细胞瘤病人的临床特征及治疗。方法回顾8例多形性黄色瘤型星形细胞瘤病人的临床资料。病人平均年龄23.7岁,肿瘤均位于大脑半球。以癫疒间起病,确诊主要依靠病理学检查。结果肉眼全切1例,显微手术全切4例,大部分切除3例;术后行放疗3例,放、化疗2例。随访10个月￣5年,6例病情稳定,癫疒间及头痛得到控制;2例复发,其中1例死亡。结论多形性黄色瘤型星形细胞瘤相对良性,癫疒间发作是最常见的症状。治疗上应尽量手术全切,对术后有残余、复发或间变者可给予化、放疗。

Objective To study the clinical characteristics and treatment of pleomorphic xanthoastrocytoma. Methods Clinical data of 8 patients, average age being 23.7 years old, with pleomorphic xanthoastrocytoma were analyzed retrospectively. The tumors were located in the cerebral hemisphere, and accompanied by epileptic seizures in the majority of cases. The diagnosis was dependent on pathological examination. Results The tumors were totally removed in 5 cases, and subtotally in 3. Five cases were treated with radiotherapy and/or chemotherapy. All the patients were followed up for 10 months to 5 years. Seizure and headache were controlled satisfactorily in 6 cases, recurrence occurred in 2 with 1 patient dead. Conclusion Pleomorphic xanthoastrocytoma is relatively benign tumor. Epileptic seizures were the main symptom. Total resection by operation should be carried out, and radiotherapy added in cases of residual tumor, relapse and malignant degeneration. The prognosis ofpleomorphic xanthoastrocytoma was generally good.