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卵母细胞体外成熟机制及分子遗传学研究进展 被引量：3

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摘要 人未成熟卵母细胞体外培养成熟(invitromaturation,IVM)是现代生殖医学的研究热点,是当今国际辅助生殖前沿技术。卵母细胞体外成熟是一个非常复杂的过程,不仅包括细胞核的成熟,也包括细胞质成熟;细胞核、质成熟的同步性至关重要,卵母细胞的发育潜能往往因二者的不同步而受阻。就IVM的临床意义、卵母细胞成熟机制、卵母细胞体外成熟非整倍体发生机理做简要综述。
作者 张文香 曹云霞
机构地区 安徽医科大学第一附属医院妇产科
出处 《国外医学（计划生育分册）》 2005年第5期243-245,共3页
关键词 卵母细胞 体外成熟机制 分子遗传学 生殖医学 染色体 纺锤体
分类号 R321 [医药卫生—人体解剖和组织胚胎学]
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参考文献16

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同被引文献22

  • 1蒋文生.新疆多浪羊品种资源的保护与开发利用[J].中国草食动物,2006,26(2):28-30. 被引量：46
  • 2Rizzo P,Raffone E,Benedetto V. Effect of the treat-ment with myo-inositol plus folic acid plus melatoninin comparison with a treatment with myo-inositolplus folic acid on oocyte quality and pregnancy out-come in IVF cycles. A prospective, clinical trial [J],Eur Rev Med Pharmacol Sci?2010,14(6) :555-561.
  • 3Tamura T,Picciano M F. Folate and human reproduc-tion[J]. Am J Clin Nutr,2006,83(5) :993-1016.
  • 4Wong W Y,Merkus H M W M, Thomas C M G,etal. Effects of folic acid and zinc sulfate on male factorsubfertility: a double-blind? randomized,placebo-con-trolled trial[J]. Fertil Steril,2002 ?77(3) :491-498.
  • 5Zhuang X J, Huang Y,Duan Y P,et al. Trans locationof active mitochondria during buffalo (Bubalus buba-lis) oocytes in vitro maturation^ fertilization and pre-implantation embryo development [J]. Reprod Do-mestic Anim,2012,47(3) :443-448.
  • 6Shane B. Folate chemistry and metabolism [J]. ClinRes Regulat Affairs,2001,18(3) : 137-159.
  • 7Pickell L,Li D,Brown K,et al. Methylenetetrahydro-folate reductase deficiency and low dietary folate in-crease embryonic delay and placental abnormalities inmice[J]. Birth Defects Res Part A:Clin Mol TeratoK2009,85(6) :531-541.
  • 8Szymanski W, Kazdepka-Zieminska A. Effect of ho-mocysteine concentration in follicular fluid on a de-gree of oocyte maturity[J]. Ginekologia Polska,2003,74(10):1392-1396.
  • 9Huang X,Gao S,Xia W, et al. Folic acid facilitatesvitro maturation of mouse and Xenopus laevis oocytes[J]. British J Nutr,2013,109(8) :1389-1395.
  • 10Kim E S,Seo J S,Eum J H, et al. The effect of folicacid on in vitro maturation and subsequent embryonicdevelopment of porcine immature oocytes [J]. MolReprod Dev,2009,76(2):120-121.

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国外医学（计划生育分册）
2005年 第5期

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