摘要
本实验研究证实:由药物引起的过敏性哮喘豚鼠的血液流变学异常,其全血粘度增高,与正常生理组比较户<0.05,具有显著意义。此外,由乙酰胆碱激发哮喘的大鼠,呈现气管环间平滑肌内微血管收缩,流速减慢,流态异常,血细胞聚集,微循环障碍。在上述动物模型中,使用红花、当归灌胃或气管表面滴药后,能使哮喘豚鼠的全血粘度降低,与哮喘模型组比较户<0.05,具有显著意义。同时,红花、当归及丹参亦可改善哮喘大鼠的气管微循环,使微血管增粗,流速加快,流态恢复正常。本实验为扩大应用活血化瘀药防治哮喘提供了理论依据。
The present experiment demonstrated that the blood viscosity of the models of asthma was higher than that of the nomal group (p<0. 05). Moreover,the rats with asthma induced by acetylcholine showed bronchial microvascular constriction and slow blood flow velocity, blood cell aggregation. The hemor-rheological disturbance in guinea-pigs was significantly relieved by Hong Hua or Dang Gui,as compared to models of asthma group(P<0. 05). Meanwhile,the microcircular failure also was lessened with bronchial mi-crocircular distention and blood flow velosity was increased. This study can provide the theoretical basis for the efficacy of Hong Hua and Dang Gui in the treatment of bronchial asthma.
