摘要
经病理证实为Ｃｒｅｕｔｚｆｅｌｄｔ－Ｊａｋｏｂ病（ＣＪＤ）９例，急性发病４例，亚急性４例，慢性１例。平均病程８．８个月。４例脑切片免疫组化染色阳性。另有３例脑活检组织匀浆接种于Ｃ５７ＢＬ／６０ｌａ，Ｂａｌｂ／ｃ和Ｗｉｓｔａｒ鼠脑内。分别于第二、三代发病。资料提示：（１）国人ＣＪＤ急性发病较多；（２）蛋白酶抗性蛋白免疫组化十分敏感；（３）ＣＪＤ脑组织活检可以成功地进行动物接种。
Ninecaseswithcreutzfildt-Jakobdisease(CJD)werepatholgoicalyconfirmed.Acuteepisodewasseeninfourcases,subcuteepisodeinfourcases,andchronicepisodeinonecase.Theaveragedurationoftheilnesswas8.8months.Immunostainusinganti-humanPrPantiserumre-vealedpositivereactionin4cases.Transmissionofthebiopsiedbrainhomogenatefromtheotherthreecasestomice(c57BL/60La,Balb/c)andratswerecarriedout,theoccuranceofthediseasecouldbeseenafter13months.OurdatacouldsuggestthattheacuteepisodesofCJDappearedtobemorepredominantinour.Countryascomparedwiththoseofthisdiseaseinsomeforeignnations.Theimmunostainwouldbesensitivemethodstodetectthisdiseaseandthepositivereactionofim-munostainusingPrPantibodyhadadefinitemeaningtodiagnosethisdisease;biopsiedmaterialsfromthepatientswithCJDcouldbesuccessfulytransmisibletoexperimentalanimals.
出处
《中华神经科杂志》
CAS
CSCD
1996年第1期29-32,共4页
Chinese Journal of Neurology
基金
中国卫生部资助
关键词
C-J病
蛋白病毒病
临床
病理
免疫组化
Creutzfeldt-JakobdiseaseImmunohistochemicalstainPrPTransmission
