摘要
目的:观察外源性白介素-1β(IL-1β)对大鼠自发活动的影响。方法:脑室注射IL-1β(60 ng/鼠,icv),以开场试验分析大鼠的自发活动。结果:脑室注射IL-1β可导致大鼠的自发活动减少。结论:脑内注射IL-1β引起大鼠的自发活动减少,但是否与抑郁症的发病有关,需进一步研究。
Objective： To investigate the effect of interleukin-1β（IL-1β） on locomotion activity in rats. Methods： IL-1β was injected intracerebwventricularly and the locomotion activity was tested by open field test.Results：The locomotion activity on rats was decreased by intracerebroventricular injection of IL-1β. Conclusion：IL-1β can decrease locomotion activity in rats.It must be further research if relating depression.
出处
《汕头大学医学院学报》
2005年第3期141-143,共3页
Journal of Shantou University Medical College
基金
国家自然科学基金资助(30370518)
关键词
行为性抑郁
白介素-1Β
自发活动
behavioral depression
intedeukin-lβ
locomotion activity
