不同营养方式对早产儿血胃动素、胃泌素水平及胃肠功能的影响

Influence of Different Nutrition Ways to Changes of Blood Motilin and Gastrin Levels in Premature Infants

目的:观察不同营养方式对早产儿空腹血中胃肠激素水平的影响,探讨合理营养方式.方法:根据对胃肠道喂养的耐受情况将82例早产儿分为全静脉营养组(早产1组,23例)、全胃肠喂养组(早产2组,34例)及微量喂养组(早产3组,25例,部分静脉营养),应用放射免疫法测定早产1～3组生后第3 d及第7 d空腹血中胃动素、胃泌素浓度.结果:①早产1～3组生后开始耐受全胃肠喂养时间分别为(11.67±3.45)d,(1.53±0.95)d及(6.46±1.34)d;②早产2、3组生后第7 d空腹血中胃动素及胃泌素水平较第3 d明显升高;③早产2、3组生后第3 d及第7 d空腹血中胃动素及胃泌素水平均高于1组(P<0.05);④早产2、3组之间第7 d胃泌素水平无统计学意义(P>0.05).早产儿胃肠激素水平与其胃肠功能成熟度呈正相关.结论:经胃肠摄入营养物能刺激早产儿胃肠激素的分泌和释放,促进其胃肠功能成熟.

Objective： To study the influence of different nutrition ways on changes of blood motilin and gastrin levels and to explore the reasonable nutrition way in premature infants. Methods： Eighty-two premature infants were derided into total parenteral nutrition group（group 1）, total enteral feeding group（group 2）and minimal enteral feeding group （group 3）by their tolerance of feeding. The blood motilin and gastrin concentrations of these three groups were determined by radioimmunoassay on day 3 and 7 after birth. Results： The meam time that the three groups could tolerate total gastrointestinal feeding was 11.67 ±3.45, 1.53 ± 0.95 and 6.46 ± 1.34 after birth respectively. The blood concentrations of motilin and gastrin on day 7 in group 2 and group 3 were higher than those on day 3. The blood concentrations of matihn and gastrin on day 3 and 7 in group 2 and group 3 were significantly higher than those in group 1. The gastrin levels between group 2 and group 3 had no statistical meaning. The blood motilin and gastrin levels were positively related to gastrointestinal function. Conclusion： Enteral nutrition can promote the growth and development of gastrointestine.