摘要
A novel room-temperature compression molding method combined with particulate leaching was(developed) to fabricate porous polyester scaffolds with the anatomical shape of the tissue or organ potentially(applied) in tissue engineering.Complicated-shaped scaffolds,such as auricle-like ones,were successfully fabricated from compression-molding putty-like mixture of concentrated poly(ε-caprolactone) solution and salt particulate in a mould with a complicated-shaped cavity at room temperature.The resultant porosity can reach over 90%.This room-temperature compression molding method is proven to be very convenient to fabricate three-dimensional porous scaffolds composed of biodegradable polymers.
A novel room-temperature compression molding method combined with particulate leaching was developed to fabricate porous polyester scaffolds with the anatomical shape of the tissue or organ potentially applied in tissue engineering. Complicated-shaped scaffolds, such as auricle-like ones, were successfully fabricated from compression-molding putty-like mixture of concentrated poly （ ε-caprolactone ） solution and salt particulate in a mould with a complicated-shaped cavity at room temperature. The resultant porosity can reach over 90%. This room-temperature compression molding method is proven to be very convenient to fabricate three-dimensional porous scaffolds composed of biodegradable polymers.
出处
《应用化学》
CAS
CSCD
北大核心
2005年第9期1024-1026,共3页
Chinese Journal of Applied Chemistry
基金
国家自然科学基金资助项目(20221402
20374015)
教育部科学技术研究重大项目(305004)
高等学校青年教师教学和科研奖励基金
"九七三"项目
"八六三"项目(2004AA215170)
上海市科技发展基金(04JC14019)资助
关键词
组织工程
多孔支架
可降解聚合物
聚Ε-己内酯
聚合物加工
tissue engineering, porous scaffold, biodegradablepolymer, poly （ ε-caprolactone）, polymer processing
