摘要
2-Amino-5-methylbenzoic acid（1） was acylated with acyl chlorides,then heated（together） with（acetic） anhydride to give 2-phenyl or 2-benzyl-6-methylbenzoxazin-4-one（3a3b）,while compound 1 was （reacted） with propanoic anhydride or trifluoroacetic anhydride to give 2-ethyl or 2-trifluoromethyl-6-methylbenzoxazin-4-one（3c3d） directly. Then,2-substituted 6-methylbenzoxazin-4-ones（3a3d） were heated together with formamide to afford 2-substituted 6-methyl-4（3H）-quinazolinones（4a4d）,which were（converted） into the title compounds（5a5d） via brominating with N-bromosuccinimide in the presence of （PhCOO）2.The structures of all the intermediates and final products were confirmed with ESI-MS,1H NMR and elemental analysis.
2-Amino-5-methylbenzoic acid （1） was acylated with acyl chlorides, then heated together with acetic anhydride to give 2-phenyl or 2-benzyl-6-methylbenzoxazin-4-one （3a - 3b）, while compound 1 was reacted with propanoic anhydride or trifluoroacetic anhydride to give 2-ethyl or 2-trifluoromethyl-6-methylbenzoxazin-4-one （3c - 3d） directly. Then, 2-substituted 6-methylbenzoxazin-4-ones （ 3a - 3d ） were heated together with formamide to afford 2-substituted 6-methyl-4 （3H） -quinazolinones （ 4a - 4d ）, which were converted into the title compounds （Sa - 5d） via brominating with N-bromosuccinimide in the presence of （PhCOO） 2. The structures of all the intermediates and final products were confirmed with ESI-MS, ^1H NMR and elemental analysis.
出处
《应用化学》
CAS
CSCD
北大核心
2005年第9期1027-1029,共3页
Chinese Journal of Applied Chemistry
基金
北京市自然科学基金资助项目(7002006
7042006)
教育部科学技术研究重点项目(2002KJ091)
