Staudinger环加成反应合成新型反式单环β-内酰胺类化合物

Synthesis of Some New Monocyclic Trans-β-Lactams Through Staudinger Cycloaddition

In view of the importance of β-lactams in the pharmaceutic research field, a series of pyrazoloderi-（vatives） of monocyclic β-lactams 2a2h was prepared from the schiff base 1a1h reactions with phthalo-（ylglycyl） chloride in the presence of triethylamine via \ cycloaddition.The structures and configurations of the（prepared） new monocyclic β-lactams were confirmed by 1H NMR,1H-1H COSY,NOESY,HMBC,HMQC methods.At 7585 ℃,compounds 2a2h were obtained in yields of 19%50% respectively.

In view of the importance ofβ-lactams in the pharmaceutic research field, a series of pyrazoloderivatives of monocyclic β-lactams 2a - 2h was prepared from the sehiff base 1a - 1h reactions with phthaloylglycyl chloride in the presence of triethylamine via [ 2 ＋ 2 ] cycloaddition. The structures and configurations of the prepared new monocyclic β-lactams were confirmed by ^1H NMR, ^1H-^1H COSY, NOESY, HMBC, HMQC methods. At 75 -85 ℃, compounds 2a- 2h were obtained in yields of 19% -50% respectively.