复合维生素E,C,B组合物面膜治疗寻常痤疮117例的疗效和安全性(英文)

Efficacy and safety of multiple vitamin E, C, B facial mask for 117 patients with acne vulgaris

目的:了解维生素E,C,B组合物面膜治疗寻常痤疮的疗效及安全性。方法:117例13a以上、痤疮严重程度分级在2级以上且主要表现于脸部的病人,予维生素E,C,B组合物面膜治疗,每日1次,共8wk。观察治疗前后痤疮数量及性质,包括粉刺、丘疹、脓疱及囊肿之数目,并评估整体疗效。结果:治疗后,粉刺、丘疹、脓疱及囊肿数目下降了13±s13,10±12,5±7及3±3,均P<0.01。7例(6.0%)病人症状完全改善,44例(37.6%)中度改善,56例(47.9%)轻度改善,10例(8.6%)无改善。59例(50.4%)病人无红肿、搔痒、灼热及脱皮等现象发生。结论:维生素E,C,B组合物面膜治疗痤疮有效,超过半数的受试者无不良反应发生,可作为传统治疗寻常痤疮药物的替代。

AIM： To evaluate the efficacy and safety of multiple vitamin E, C, B facial mask for the patients with acne vulgaris. METHODS： One hundred and seventeen patients aged over 13 a, with acnes mainly sited on the face and an acne severity rating above grade 2 were enrolled in this study. The mask treatment was used once a day with 8 wk as a course. The primary endpoint included the number and the degree of acne lesions including comedoes, papules, pustules and cysts. The secondary endpoint was the overall efficacy evaluation by the physicians. RESULTS： After 8 wk of treatment with multiple vitamin E, C, B facial mask, the mean number of acne lesions： comedoes, papules, pustules and cysts decreased 13 ± s 13, 10 ± 12, 5±7 and 3 ± 3, respectively. These changes were statistically significant （P 〈0.01 ）. The results of overall efficacy evaluation showed that 7 patients＇ （6.0 % ） symptom was greatly improved, 44 patients＇ （37.6 % ） symptoms were moderately improved, 56 patients＇ （47.9 % ） symptoms were slightly improved, and 10 patients＇symptoms did not change. Among all 117 patients, 59 patients （50.4 %） showed no adverse reactions, including swelling, redness, itching, burning or scaling. CONCLUSION ： Multiple vitamin E, C, B facial mask is efficacious for the treatment of ache and more than half study subjects experienced in none adverse reaction. Multiple vitamin E, C, B facial mask possesses an alternate therapy in acne vulgaris.