草分枝杆菌F·U·36治疗反复发作呼吸道感染病儿45例

Mycobacterium phlei F·U·36 injection in treatment of 45 children with reiterative respiratory tract infections

目的:观察草分枝杆菌F·U·36治疗反复呼吸道感染(RRSI)病儿临床疗效.方法:75例RRSI病儿分为2组,其中反复上呼吸道感染50例,反复下呼吸道感染25例.治疗组45例中男性25例,女性20例,年龄(6±s 6)a,1.5～14.1 a,给予青霉素及利巴韦林注射液,iv,gtt,bid,7～10 d;在以上常规治疗的基础上,给予草分枝杆菌F·U·361.72μg,im,每周1次,1 mo为一个疗程.对照组30例,男性17例,女性13例,年龄(6±7)a,1.4～14.5 a,只给予常规治疗.观察2组临床疗效,并测定IgA,IgG,IgM,CD3+,CD4+,CD8+,CD4+/CD8+的水平.结果:治疗后治疗组,总有效率91%(41/45);对照组总有效率37%(11/30),2组比较差异有非常显著意义(P＜0.01).治疗组治疗后,IgA,IgG,IgM,CD3+,CD4+,CD8+,CD4+/CD8+值均明显增加(P＜0.01).结论:草分枝杆菌F·U·36用于防治RRSI有明显疗效,能有效地改善免疫学指标,无明显不良反应.

AIM ： To observe the therapeutic effect of Mycobacterium phlei F · U · 36 injection in treating children with reiterative respiratory tract infections. METHODS：Seventy-five children with reitera- tive respiratory tract infections （RRSI） were separated into two groups, including 50 children with upper RRSI and 25 children with inferior RRSI. Fortyfive children in the treatment group （ M 25, F 20 ; age （6 ± s 6 ） a, 1. 5±14. 1 a） received benzylpenicillin and ribavirin injection, iv, gtt,bid,7-10 d; and then, was furthermore treated with Mycobacterium phlei F · U· 36 injection 1 mL, im, once a week for four weeks. The control group of 30 children （M 17, F 13; age（6±7） a, 1.4-14.5 a） received only the above conventional treatment without Mycobacterium phlei F · U · 36 injection. The effects on two groups were observed and the IgA, IgG, IgM, CD3^＋ , CIM ^＋ , CD8 ^＋ , CIM ^＋/CD8^＋ level in both groups were measured before and after the treatment. RESULTS：After treat ment, the total effective rate was 91% （41/45） in the treatment group, and 37 % （11/30） in the control group showing a significant difference between the two groups with significant enhanced （ P 〈 0. 01 ） , level of IgA, IgG, IgM, CD3^＋, CIM^＋, CD8^＋, CIM^＋/CD8^＋ in treatment group. CONCLUSION： Mycobacterium phlei F · U · 36 is an effective agent in the treatment of RRSI without obvious adverse reaction.