米氮平与帕罗西汀治疗伴有焦虑症状抑郁症的对照研究

Mirtazapine Compared with Paroxetine in Depressed Patients with Anxiety Symptoms

目的:比较米氮平与帕罗西汀治疗伴有焦虑症状抑郁症的疗效。方法:将符合CCMD-3抑郁症诊断标准的60例患者随机进入米氮平或帕罗西汀组接受治疗,分别在治疗0、1、2、4、6周末评定HAMD 总分及HAMD 焦虑/躯体化因子分。结果:米氮平与帕罗西汀疗效相当,米氮平起效较快,早期即具明显的抗焦虑作用。结论:米氮平对伴有焦虑症状的抑郁症有良好的疗效。

Objective： To compare the efficacy of mirtazapine with that ofparoxetme. Methods： 60 patients with a diagnosis of major depressive episode （CCMD-3） were randomly assigned to 6 weeks of treatment with mirtazapine or paroxetine, Efficacy was assessed with HAM-D-17 at the end of baseline and 1,2,4,6 weeks after treatment. Results： Both medications had comparable efficacy. Mirtazapine responded more quickly and showed significant improvement of anxiety symptoms at the beginning of the treatment. Conclusion： mirtazapine had good effectiveness in the depressed patients with anxiety symptoms.