开窍通腑法对急性脑损伤保护作用的实验研究

Experimental Study of Protective Effect in Acute Brain Damage by the Method of Kai-Qiao and Tong-Fu

目的:探讨开窍通腑同治法与单纯开窍、通腑法对大鼠脑保护的影响。方法:双侧颈总动脉结扎复制大鼠脑缺血模型,观察脑组织含水量、电镜形态学改变及血清SOD、MDA、NO的含量变化。结果:开窍通腑法的代表方牛黄承气汤在降低脑组织含水量、形态学改变及SOD、MDA、NO的变化明显优于其他各组。结论:开窍通腑合用较单一开窍或通腑更具有保护脑损伤的作用。

Objective： To study the effect on brain protection in rats by employing the method of Kai-Qiao binding with Tong-Fu and that of Kai-Qiao or Tong-Fu respectively. Methods ： The model of cerebral ischemia in rats were made by deligating both the common carotid artery, Then the water dose contained in cerebral constitution, the change of morphology under the electron microscope and the dose of SOD,MDA, NO in serum were observed. Results ： Compared with other groups, the changes of index mentioned above was better after the Niuhuangchenqi decoction was administrated which is the representative preparation in the method of Kai-Qiao and Tong-Fu. Conclusion ： The effect on brain protection by employing the method of Kai-Qiao and Tong-Fu together is better than either of methods alone.