代谢异常与急性脑梗死患者医院感染的调查研究

Metabolic Impairments and Nosocomial Infection in Acute Brain Infarction Patients

目的探讨急性脑梗死患者发生医院感染与空腹血糖(fasting blood glucose,FBG)和血脂水平的关系,以便采取有效措施,降低医院感染的发生率. 方法收集2004年1～12月首次因急性脑梗死在本院神经内科住院患者的资料,根据空腹血糖分为空腹血糖异常组(impairment of fasting blood glucose, IFG)和空腹血糖正常组(normal fasting blood glucose, NFG),进行回顾性分析. 结果符合条件患者378例,发生医院感染者42例,感染率为11.11%;其中IFG组132例,医院感染者20例,感染率为15.15%,NFG组246例,医院感染者22例,感染率为8.94%;两组间FBG、TG差异均有显著性,HDL、TC和LDL两组间差异无显著性;多元Logistic回归分析显示,IFG和TG异常与医院感染明显相关. 结论急性脑梗死IFG患者医院感染率升高可能与潜在糖尿病有关,单纯IFG或血脂异常也可能与其医院感染有关.

OBJECTIVE To study the effects of glucose and lipid impairments on nosocomial infection in acute brain infarction patients. METHODS The clinical data of acute brain infarction inpatients were collected, divided into two groups [impairment of fasting blood glucose （IFG）, and normal fasting blood glucose （NFG）] and analyzed. RESULTS The nosocomial infection rate （NIR） of 378 acute brain infarction cases was 11. 11%, of which, 132 cases with IFG, NIR 15. 15%, 246 with NFG, NIR 8. 94%. Significant difference was seen in fasting blood glucose （FBG）, triglyceride （TG） between two groups. But there was no difference in total cholesterol （TC）, high density lipoprotein （HDL） and low density lipoprotein （LDL）. Binary logistic analysis showed that IFG and higher TG were related with nosocomial infection in acute brain infarction patients. CONCLUSIONS It is probably undiagnosed diabetes mellitus that might be an important factor for the high NIR in acute brain infarction patients. But further study is still needed to confirm the relationship between NIR and IFG or dyslipidemia in acute brain infarction patients.