美罗培南治疗呼吸机相关性肺炎的临床研究

Effect of Meropenem on Ventilator-associated Pneumonia

目的比较美罗培南与亚胺培南/西司他丁治疗呼吸机相关性肺炎的有效性和安全性。方法采用随机对照设计,观察美罗培南与亚胺培南/西司他丁治疗60例呼吸机相关性肺炎的临床疗效和不良反应。结果美罗培南组30例,治疗有效率为90.0%,细菌清除率为83.3%;亚胺培南/西司他丁组30例,治疗有效率为86.7%,细菌清除率为82.1%;两组间差异无显著性;两组不良反应发生率均为6.7%。结论美罗培南治疗呼吸机相关性肺炎与亚胺培南/西司他丁相当,安全高效。

OBJECTIVE To compare the effect and safety between meropenem and imipenem. METHODS A randomized comparative study was conducted to compare the clinical effect and safety of meropenem versus imipenem in the treatment of 60 cases of ventilator-associated pneumonia. RESULTS Thirty patients of ventilator- associated pneumonia were enrolled into meropenem group with an effective rate of 90. 0% and bacteriological eradication rate of 83.3%. On the other hand, thirty patients of ventilator-associated pneumonia were enrolled into imipenem group with an effective rate of 86.7% and bacteriological eradication rate of 82.1%. There was no significant difference between two groups. The rate of adverse reaction for both meropenem and imipenem was 6.7%. CONCLUSIONS Meropenem is safe and effective to ventilator-associated pneumonia.