耐亚胺培南铜绿假单胞菌医院感染现状及监测

Nosocomial Infection and Antimicrobial Resistance Surveillance among Imipenem-resistant Clinical Isolates of Pseudomonas aeruginosa

目的探讨耐亚胺培南铜绿假单胞菌医院感染现状及其对13种常用抗菌药物的耐药性,指导临床合理选用抗菌药物。方法用常规方法对289株铜绿假单胞菌临床株进行鉴定,并采用Kirty-Bauer法选用13种抗菌药物进行药物敏感试验。结果106株耐亚胺培南铜绿假单胞菌的分离率为36.7%,主要来源于痰标本,占78.3%;其在临床病区分布中居前3位者依次为呼吸内科、神经外科、老年病科;106株铜绿假单胞菌对氯霉素、复方新诺明等8种抗菌药物均表现出>50%的耐药率。结论耐亚胺培南铜绿假单胞菌医院感染严重,对抗菌药物呈多重耐药,治疗此类细菌感染宜参考细菌药敏结果合理选用抗菌药物。

OBJECTIVE To investigate the nosoeomial status and drug resistance spectrum of imipenem-resistant Pseudomonas aeruginosa. METHODS VITEK32 was used for the identification of 289 P. aeruginosa clinical isolates and the resistance of 13 kinds antibiotics was determined by Kirby-Bauer method. RESULTS Totally 106 strains of imipenem-resistant P. aeruginosa were mainly isolated from departments of respiratory diseases, neurosurgery and geriatrics, most of them were from sputum （78.3%）. Result of susceptibility test showed that P. aeruginosa was highly resistant to ehloramphenieol, SMZ, etc. The trend of multidrug resistance of imipenemresistant P. aeruginosa was increasing. CONCLUSIONS The status of nosoeomial infection caused by imipenemresistant P. aeruginosa is very serious, and these strains show multidrug resistance. To control this kind of infection, we must choose antibiotic rationally according the result of susceptibility test.