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多聚ADP核糖聚合酶与帕金森病关系的研究进展 被引量：4

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摘要 DNA损伤断裂可以激活多聚 ADP核糖聚合酶,引起多种核蛋白发生聚 ADP核糖化。多聚 ADP核糖聚合酶被过度活化后消耗大量 NAD^+和 ATP可以诱导细胞凋亡或坏死。多聚 ADP核糖聚合酶参与了帕金森病的发病机制,多聚ADP核糖聚合酶抑制剂对帕金森病起保护作用。
作者 王东玉 张朝东
机构地区 中国医科大学附属第一医院神经内科
出处 《国外医学（老年医学分册）》 2005年第5期208-211,共4页 Foreign Medical Sciences(Geriatrics)
关键词 多聚ADP核糖聚合酶 帕金森病 DNA损伤修复 多聚ADP 聚合酶 核糖 诱导细胞凋亡 DNA损伤 发病机制 保护作用
分类号 R742.5 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献15

  • 1Jean-Christophe Am e, Spenlehauer C, Gilbert de Murcia.The PARP superfamily. Bio Essays, 2004; 26; 882-893.
  • 2Burkle A, Diefenbach J, Brabeck C et al. Ageing and PARP. Pharmacol Res, 2005; 52 (1): 93-99.
  • 3Komjati K, Besson VC, Szabo C. Poly (ADP-ribose)polymerase inhibitors as potential therapeutic agents in stroke and neurotrauma. Curr Drug Targets CNS Neurol Disord, 2005; 4 (2): 179-194.
  • 4Burkle A, Brabeck C, Diefenbach J et al. The emerging role of poly (ADP-ribose) polymerase-1 in longevity. Int J Biochem Cell Biol, 2005; 37 (5): 1043-1053.
  • 5Nguewa PA, Fuertes MA, Valladares B et al. Poly (ADP-ribose) polymerases: hornolcgy, structural domains and functions. Novel therapeutical applications. Prog Biophys Mol Biol, 2005; 88 (1): 143-172.
  • 6Gilliams-Francis KL, Quaye AA, Naegele JR. PARP cleavage, DNA fragmentation, and pyknosis during excitotoxin-induced neruonal death. Exp Neurol, 2003; 184(1) : 359- 372.
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同被引文献33

  • 1王东玉,商秀丽,张朝东.PJ34对帕金森病模型小鼠黑质多巴胺能神经元保护的实验研究[J].中国老年学杂志,2006,26(12):1688-1690. 被引量：2
  • 2Tiago FO, Grammatopoulos TN, Ahmann S, et al. Pharmacological inhibition of PARP-1 reduces alpha-synuclein- and MPP + -induced cytotoxicity in Parkinson's disease in vitro models(J). Biochem Biophys Res Commun ,2007 ;357 ( 3 ) :596602.
  • 3Heeres JT, Hergenrother PJ. Poly (ADP-ribose) makes a date with death [ J]. Curr Opin Chem Biol,2007 ; 11 (6) :644-53.
  • 4Moubarak RS, Yuste VJ, Artus C, et al. Sequential activation of poly (ADP-ribose) polymerase 1 ,calpains,and Bax is essential in apoptosis- inducing factor-mediated programmed necrosis(J). Mol Cell Biol,2007; 27( 13 ) :4844-62.
  • 5Xiao CY, Chen M, Zsengeller Z, et al. Poly (ADP-Ribose) polymerase protnotes cardiac remodeling contractile failure, and translocation of apoptosis-inducing factor in a routine, experimental model of aortic banding and heart failure [ J ]. J Pharmacol Exp Ther,2005 ; 312 : 891-8.
  • 6Li GY, Osborne NN. Oxidative-induced apoptosis to an immortalized ganglion cell line is easpase independent but involves the activation of poly (ADP-Ribose) polymerase and apoptosis-indueing factor[ J]. Brain Res, 2008 ; 1188 (10) :35-43.
  • 7Yu SW, Andrabi SA, Wang H, et al. Apoptosis-indueing factor mediates poly(ADP-ribose) ( PAR ) polymer-induced cell death [J]. Proc Natl Acad Sci U S A,2006;103(48) :18314-9.
  • 8Moroni F. Poly(ADP-ribose) polymevase 1 ( PARP-1 ) and postischemic brain damage [ J]. Curr Opin Pharmacol, 2008 : 8 ( 1 ) : 96-103.
  • 9Mabley JG, Horvath EM, Murthy KG, et al. Gender differences in the endotoxin-induced inflammatory and vascular responses: potential role of poly(ADP-ribose) polymerase activation [ J ]. J Pharmacol Exp Ther, 2005, 315(9): 812-820.
  • 10Ame JC, Spenlehauer C, de Murcia G. The PARP superfamily[ J]. Bio Essays, 2004, 26 (8) : 882 - 893.

引证文献4

二级引证文献3

国外医学（老年医学分册）
2005年 第5期

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