尿激酶型纤溶酶原激活剂在胶质母细胞瘤中表达及意义

Expression and Significance of Urokinase-type Plasminogen Activator in Glioblastoma

目的研究尿激酶型纤溶酶原激活剂(urokinase-typeplasminogenactivator,uPA)在胶质母细胞瘤中的表达及临床意义。方法应用免疫组化LSAB法检测30例胶质母细胞瘤中uPA的表达,结合临床随访,使用Cox回归统计分析。结果uPA染色定位于肿瘤细胞和血管内皮细胞。Cox回归分析显示uPA是影响生存时间的一个独立的预后因子,它与预后存在一定的负相关关系。结论uPA可能是预测胶质母细胞瘤预后的一个独立的预后因子。

Objective To study expression and clinical significance of uPA in glioblastoma. Methods Applying LSAB（ labelled streptavidin biotin method） immunohistochemical technique, expression of uPA was studied in 30 patients with glioblastoma and follow - up survey with Cox regression analysis. Results The staining for uPA was localized on tumor cells and endothelial cells. Cox regression analysis showed that uPA was an independent prognostic factor affecting survival and it had a negative correlation with the prognosis. Conclusion UPA appears to be an independent marker for predicting prognosis of glioblastoma.