抑郁症患者血浆皮质醇、血浆催乳素及地塞米松抑制试验的研究

Plassma cortisol, Plassma prolactin and dexamethasone suppression test in patients with depression

目的:从神经内分泌角度探讨抑郁症的生化病理机制.方法:采用放射免疫测定法,分别测定64例抑郁病患者和59名正常对照者血浆皮质醇、血浆催乳素的含量,并进行地塞米松抑制试验(DST).结果:抑制症组血浆基础皮质醇水平(387±165)nmol/L高于正常对照组(269±152)nmol/L,差异具非常显著性(P＜0.01),而血浆催乳素水平(336±185)nmol/L与对照组(295±136)nmol/L相比,差异性显著(P＞0.05),抑郁症组DST阳性率为26％～19％与正常对照组16％～11％相比差异无显著性(P＞0.05).结论:抑郁症患者存在神经内分泌功能紊乱.

Objective： To explore the neuroendocrine in parents with depression. Methods ：64 patinets with depression and 59 health controls were involved in the study. Plasma cortisol and plasma prolastin level was measured with redioimmunoassay. The dexamethasme suppression test （DST） was conducted as well. Results： Plasma basal cortisol level at 8am was significantly higher in depression patients than in control （P 〈 0.01 ）, plasma prolactin level had no significant difference between the two groups （P 〉 0.05）. The positive rate of DST in depression was （26% - 19% ） , which was not significant difference between the patients group and the control （16% - 11%, P 〉 0.05 ）. Conclusions ：There are neuroendocine impairments in depression patients, which supports the hypothesis of nenroendocine dysfunction in depression.