摘要
目的探讨复方积雪草胶囊对局灶节段性肾小球硬化症(FSGS)大鼠肾组织细胞外基质(ECM)的影响。方法建立单侧肾切除合并阿霉素静脉双次注射大鼠FSGS模型,采用半定量病理分析法观察复方积雪草胶囊对肾组织ECM的影响,并生化检测尿蛋白、血脂、肾功能的变化。结果FSGS大鼠经复方积雪草胶囊治疗8周后,肾组织ECM积聚减少(P<0.01),血脂、肌酐、尿素氮和尿蛋白较模型组明显降低(P<0.05～0.01),疗效优于尿毒清组。结论复方积雪草胶囊可以抑制肾组织ECM积聚,改善肾功能,防治肾纤维化。
Objective:To investigate the effects of centella asiatica compound capsule on the renal extracellular matrix in rat models with focal segmental glomerulosclerosis.Methods:Unilateral nephrectomy followed twice by intravenous injection of adriamycin then rats were treated with cenella asiatica compound capsule 8 weeks.Pathologic staining of renal sections was performed by semi-quantitative analysis of computerized image scanning.blood lipoids,kidney function and protein were tested automatic biochemical analysis system.Results:Centella asiatica compound capsule was capable of reducing urinary protein excretion,lowering blood lipoid,depressing the deposition of ECM as compared with that of the control group.the effect was better than that of niaoduqing group. Conclusion:Centella asiatica compound capsule can inhibit the deposition on renal ECM and improve renal function,thereby playing an important role in prevention and treatment of renal fibrosis.
出处
《中国中医药科技》
CAS
2005年第5期274-276,共3页
Chinese Journal of Traditional Medical Science and Technology
基金
浙江省科技厅资助项目No.11095
浙江省中医药管理局重点资助项目No.2002KF006
