一种新颖的抗血栓材料的研究

The Study on a Novel Anticoagulative Material

聚氨酯和肝素经低温等离子体表面处理后，直接以共价键形式结合，在聚氨酯管的内壁生成了光滑的聚氨酯－肝素接枝共聚体。经全血凝固时间的检测，新鲜人血注入聚氨酯－肝素接枝管后搁置５昼夜，电镜检查其管壁未见血栓痕迹。凝血酶时间等检测表明，接枝管起着抗血液凝固的功效，且肝素不脱落。经红外光谱测试，差谱中的新吸收谱带１１６５和１３３９ｃｍ￣（－１）表明聚氨酯和肝素分子之间生成了新共价键Ｎ－ＳＯ＿２或Ｏ－ＳＯ＿２的ＳＯ＿２官能团的对称和反对称伸缩振动。

The heparin has been grafted directly on the surface of polyurethane with the help of hypothermia plasma treatment. The smooth polyurethane-heparin graft copolymer is deeped in the inside tube wall. By dotting time (CT)test fresh human blood is injected to the polyurethane-heparin graft tube,after 5 days and nights there isn' t any thrombin the inside tube wall. By kaolin partial thomboplastin time (KPTT), prothrombin time(PT)and thrombin time (TT)tests to these polyurethane-heparin graft tubes, the results are that,this novel graft tube has anticoagulation visibly and there isn't falling free heparin from the tube wall, In infrared spectrum peaks 1165 cm￣(-1) and 1 339 cm￣(-1) are symmetric and antisymmetric stretch vibrations of SO_2 group in new covalent bond N-SO_2 or O-SO_2.