精神分裂症患者发病年龄与临床特征的相关性研究

Relationship between age at onset and clinical features in schizophrenia patients.

目的探讨精神分裂症发病年龄与临床特征的关系。方法对符合DSM-IV精神分裂症诊断标准的294例住院患者进行BPRS评估和BEAM检查,并收集其人口学资料和病史资料。结果BPRS总分和迟滞因子分与发病年龄呈负相关,而BPRS总分、迟滞因子分和敌对猜疑因子分与未治疗期的长短呈正相关。发病年龄在性别和遗传因素中的差异无显著性,而在发病诱因、BEAM检查结果和诊断类型间的差别有统计学意义。结论精神分裂症的临床特征与发病年龄明显相关,发病年龄越小病情越严重,阴性症状也越突出,提示在制定治疗康复方案方面,应有所区别。

Objective To investigate the relationship of age at onset with clinical features in schizophrenia patients. Methods A total of 294 inpatients met the criteria of DSM-IV for schizophrenia were included in the study. Assessment instruments were brain electric activity mapping（BEAM）and brief psychiatric rating scale （BPRS）. Clinical data and demography data were collected. Results The total score and anergia factor-score of BPRS had negative correlation with age at onset. The total score,anergia factor-score and hostile-suspiciousness factor-score of BPRS had positive correlation with untreated time. The age at onset of schizophrenia had no difference in gender and genetic factor,but had differences in motivation, results of BEAM and type of diagnosis. Conclusions The clinical features of schizophrenia correlate with age at onset. The age at onset is younger, the condition would be severer and the negative symptoms would be prominenter.