帕罗西汀与氯硝西泮治疗广泛性焦虑症的对照研究

A comparative study of paroxetine and clonazepam in the treatment of patients with generalized anxiety disorder.

目的探讨帕罗西汀治疗广泛性焦虑症的临床疗效及副反应。方法采用随机分组的方法,将符合CCMD-3诊断标准的86例广泛性焦虑症分为帕罗西汀组(43例),氯硝西泮组(43例),疗程6周,用焦虑自评量表(SAS)Hamilton焦虑量表(HAMA)和副反应量表(TESS)评定疗效和副反应。结果氯硝西泮和帕罗西汀对广泛性焦虑症均有显著疗效,两组间无显著性差异(P〉0.05)。两药不良反应比较差异也无显著性(P〉0.05)。结论帕罗西汀治疗广泛性焦虑安全、有效。

Objective To study the clinical efficacy and side effects of paroxetine in the treatment of generalized anxiety disorder. Methods Eighty-six patients who met the criteria of CCMD-3 for generalized anxiety disorder were randomly assigned to treatment with paroxetine （43 patients） or clornazepam （43 patients） for 6 weeks. The clinical efficacy and side effects were tested with HAMA,SAS and TESS. Results Paroxetine was similar to clonazepam in clinical efficacy and side effects. Conclusion Paroxetine is an effective and safe anxiolytic agent.