大环二萜化合物的研究ⅩⅥ．（±）－Malabaric　Acid和Anisomelol前体化合物的合成

Studies on Macrocyclic DiterpenoidsⅩⅥ.Synthesis of Precursors for(±)-Malabaric Acid and Anisomelol

以香叶醇（３）和高香叶基碘（６）为起始原料合成了（±）－ＭａｌａｂａｒｉｃＡｃｉｄ（１）和Ａｎｉｓｏｍｅｌｏｌ（２）前体化合物９和１１，合成中的关键步骤是化合物５和７的Ｗａｄｓｗｏｒｔｈ－Ｅｍｍｏｎｓ反应以及化合物８和１０的烯丙型区域选择性氯化重排。

Trimethyl-7-ethoxylcarbonyl- 14-chloro-2E,6Z,10E,15-hexadecatetraenyl phenylsolfone and 3,11,15-trimethyl-7-[(2-tetrahydropyranoxy)methyl]-14-chloro-2E,6Z,10E,15-hex-adecatetraenyl phenylsolfone,the precursore of(±)-malabaric acid and anisomelol,have been synthesized from geraniol and homogeranyl iodine.The key steps in synthesis are Wadsworth-Emmons condensation and regioseiective allylic chlorination.